Sustained Delivery Fluocinolone Acetonide Vitreous Implants
نویسندگان
چکیده
منابع مشابه
Safety and pharmacokinetics of an intraocular fluocinolone acetonide sustained delivery device.
PURPOSE To determine the safety and pharmacokinetics of an intraocular fluocinolone acetonide sustained drug delivery device. METHODS Nonbiodegradable drug delivery devices containing 2 or 15 mg of a synthetic corticosteroid, fluocinolone acetonide, were constructed. The long-term in vitro release rates of these devices were determined in protein-free buffer or buffer containing 50% plasma pr...
متن کاملEfficacy of low-release-rate fluocinolone acetonide intravitreal implants to treat experimental uveitis.
OBJECTIVE To determine the efficacy of 0.5-mg and 0.1-mg sustained-release fluocinolone acetonide intravitreal implants to inhibit ocular inflammation in a rabbit model of severe uveitis. METHODS The in vitro pharmacokinetic profile of both the 0.5-mg and 0.1-mg sustained-release fluocinolone intravitreal implants was determined during a 10-day period. A sustained-release fluocinolone acetoni...
متن کاملIntraocular pressure in patients with uveitis treated with fluocinolone acetonide implants.
OBJECTIVE To report the incidence and management of elevated intraocular pressure (IOP) in patients with uveitis treated with the fluocinolone acetonide (FA) intravitreal implant. DESIGN Pooled data from 3 multicenter, double-masked, randomized, controlled, phase 2b/3 clinical trials evaluating the safety and efficacy of the 0.59-mg or 2.1-mg FA intravitreal implant or standard therapy were a...
متن کاملLong-term follow-up of patients treated with multiple fluocinolone acetonide implants for noninfectious uveitis
PURPOSE To evaluate long-term outcomes in eyes undergoing exchange of fluocinolone acetonide intravitreal implants for noninfectious uveitis. METHODS In this retrospective case series, chart review was conducted of all patients treated for noninfectious uveitis with fluocinolone acetonide implants. All patients were seen at a single center between 2007 and 2010.We studied eight eyes of eight ...
متن کاملFluocinolone acetonide intravitreal sustained release device – a new addition to the armamentarium of uveitic management
Uveitis is a potentially sight-threatening inflammatory eye disease caused by multiple infectious and non-infectious etiologies for which the standard of care involves corticosteroids or various immunomodulary therapy (IMT) drugs. These available treatments, although effective, may cause significant morbidity and sometimes mortality in uveitis patients due to their toxic side-effects and the ne...
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ژورنال
عنوان ژورنال: Ophthalmology
سال: 2014
ISSN: 0161-6420
DOI: 10.1016/j.ophtha.2014.04.019